Bestseller

4.8 (134)

Therapeutic Strength Digestive Enzymes

Clinically dosed at 40,000 FIP (40,000 USP) lipase, 100,000 HUT protease (650,000 USP), and 3,755.55 SKB (180,264 USP) amylase, our patent-pending digestive enzymes are designed for those looking for true relief.

Our potency comes from purity: single-source enzymes, small-batch microbial fermentation, and enhanced filtration. We never use blends, plasticizers, phthalates, sulfates, or dyes. Just pure, undiluted enzymes made locally in our cGMP-certified facility.

Patent-pending and uniquely designed to be active and potent in both the stomach and the small intestine without needing an enteric coating. Full spectrum, clean, and properly dosed pancreatic support for complete digestive relief. No prescription required.

Real potency. Real results.

HSA/FSA eligible with

More effective than prescription!

Bryce M.Verified buyer

Finally... I feel normal after eating!

Kaye P.Verified buyer

The best OTC digestive enzymes

Art M.Verified buyer

Supports healthy, efficient digestion
Maximizes nutrient absorption
Promotes sustained energy + daily comfort

Clinician’s Choice

9 out of 10 doctors surveyed recommended BoulderBio Therapeutic Digestive Enzymes for daily use.

Description

Unmatched in potency, purity, and standards, this clinically dosed formula is made from single-source enzymes using small-batch microbial fermentation and enhanced filtration. It’s designed to remain active in both the stomach and small intestine—without the use of coatings or harmful solvents. BoulderBio is the first and only pharmaceutical-grade digestive support available OTC, delivering a level of quality and efficacy you won’t find anywhere else.

How To Use

Ingredients

BoulderBio is the most potent digestive enzyme available without a prescription—clinically dosed at 40,000 FIP LIPASE, 100,000 HUT PROTEASE, and 3,755 SKB AMYLASE.

One Daily Habit for Whole-Gut Support

You may have enzyme deficiency and not even know it. The simplest way to determine if digestive enzymes can solve your ailments is to try them.

Good For

gas

bloating

Low energy

Inflammation

discomfort

bacterial overgrowth

Our enzymes are for optimal digestive support, with exact dosing and rigorous testing you can trust.

88%

experienced symptom relief with as few as 1–2 capsules per meal⁷
73%

average reduction in bloating and abdominal discomfort across all patients^{3, 7}
79%

of all symptoms related to pancreatic insufficiency decreased within the first 21 days^{3, 7}

See The Science

The 3 Proven Enzymes Your Body Needs To Break Down Food

Lipase 40,000 FIP

At 40,000 FIP, lipase breaks down fats for better absorption, so you feel lighter after meals with less bloating and more energy.

*FIP is equivalent to USP.²

Protease 100,000 HUT

At 100,000 HUT, protease supports protein digestion to help your body repair muscle, strengthen immunity, and recover faster.

Amylase 3,755 SKB

At 3,755 SKB, amylase turns carbohydrates into usable energy, helping prevent energy crashes and keeping you steady throughout the day.

Daily Digestive Support That Adds Up

1 Day

1 Week

4 Weeks

10 Weeks

1 Day

Relief from common digestive symptoms can begin after your first meal, making digestion feel easier and more comfortable.

relieves:

gas

bloating

discomfort

1 Week

Improvement in post-meal fatigue, loose stools, bloating, and urgency may become noticeable, helping digestion feel more stable and predictive.

relieves

fatigue

loose stools

bloating

urgency

4 Weeks

Reductions in digestive irritation, gut reactivity, and inflammation from undigested food may be experienced, supporting a calmer, more comfortable digestive system.

Relieves:

irritation

gut reactivity

inflammation

10 Weeks

Benefits may extend beyond digestion, with improvements in cognitive clarity, nutrient absorption, energy levels, digestive consistency and resilience, microbial balance, and immune signaling.

Relieves:

low energy

brain fog

immune strain

	Enzymedica Digest Gold	Vital Nutrients Pancreatin Enzymes	Thorne Pancreatic Enzymes
Vegan
Available without a prescription
Clinically-proven dosage
Active in stomach and small intestine
Free from fillers and additives
	Leading Prescription Enzyme A	Leading Prescription Enzyme B	Leading Prescription Enzyme C
Vegan
Available without a prescription
Clinically-proven dosage
Active in stomach and small intestine
Free from fillers and additives

Designed to Exceed Industry Standards

Each enzyme batch is produced in controlled, limited runs to ensure the highest level of care and consistency.

ABOUt US

Changed my life

I have Alpha Gal Syndrome and pancreatic problems. These enzymes are mammal free.

Affordable alternative to Creon

After my Whipple procedure, I was prescribed Creon, which worked well, but even with insurance it was way too expensive. Looking for a more affordable option, I found Boulder Bio digestive enzymes and decided to give them a try.

It takes time to find the right dose, and I’m still not quite there yet, but they work well and have been comparable to Creon. While Boulder Bio’s cost is still on the higher end of over-the-counter digestive enzymes, the quality is better than other cheaper brands, and the cost is more manageable than Creon. I’m glad to have found an effective alternative that supports my digestion without the hefty prescription price tag.

Miracle medicine!

I was in so much pain before I tried Boulder Bio. Sadly I discovered that I am allergic to the pig pancreas enzyme. Severe reaction. I’ve been pain free since taking it - 3 capsules with each meal and 2 with a snack. Wonderful!

Whipple support

Unfortunately, your enzymes are not working as well as CREON. I’m getting more bile reflux and am not feeling good when I eat. I’m not tolerating as many foods as I was before I switched to your enzymes. I was looking for a more affordable pancreatic enzyme as CREON has gone through the roof.

Relief from indigestion

I had to quit taking pancreatic enzymes because they cost too much. I looked for alternatives and found BoulderBio. My gastroenterologist said the enzyme strength was the same as the porcine enzymes and to try it. I’ve been taking it for over a month and it works! I lost the bulb of my pancreas during Whipple surgery five years ago.

Great product to get rid of big parma

The product helped me get off Parma

Hmmm

Haven't noticed a difference yet.

So Thankful!!

My adult son was diagnosed a couple of years ago with EPI and has tried both Creon and Pancreaze. They helped some, but are cost prohibitive. He had run out of medication and was feeling hopeless. I recently found BoulderBio online and he agreed to try it. Honestly, neither of us was expecting much, but were hoping that it was better than nothing. Imagine our delight when they actually worked! It’s only been 8 days and he confirmed today that BoulderBio is working better than both of the other prescriptions ever did!

Thank You, Boulder Bio is great.

Subscribed to their plan and they have shipped as I needed the product.
Thank You, the digestive enzymes work great. Just the product that my system was missing.

Frequently
Asked Questions

All FAQs

What are digestive enzymes and what do they do?

How do I know if digestive enzymes will work for me?

If you suffer from gas, bloating, low energy, pain or sleepiness after eating, inflammation, bacterial overgrowth, or other gastrointestinal discomfort, you may have enzyme deficiency and not even know it. The simplest way to determine if digestive enzymes can solve your ailments is to try them!Enzyme deficiency is far more common than most people think and causes a variety of symptoms. These symptoms are often misattributed by doctors, resulting in an incorrect diagnosis. According to Healthline, pancreatic insufficiency (aka lack of digestive enzymes) is the Number 1 missed diagnosis out of all gastrointestinal conditions. Even when doctors do test for pancreatic function, the test has a high specificity, but a low sensitivity. Basically, this means that it is great at confirming pancreatic insufficiency in the most severe cases, but lower levels of pancreatic insufficiency are not detected. Unfortunately, many of these individuals can go years, decades, or longer living with unresolved GI distress. We will share many of these case studies to our email subscribers as they are what led to BoulderBio's founding.

Why is indigestion a cause for concern?

Undigested food is problematic for two reasons:The nutrients in undigested food are unable to be absorbed by the body, which can cause symptoms such as low energy, brain fog, malnourishment, vitamin deficiency, anxiety, etc.Food is not meant to remain in the digestive tract when undigested, so when it does, it causes symptoms such as inflammation, discomfort (gas, bloating, nausea, etc.), bacterial overgrowth, and more

How is BoulderBio’s formulation superior?

Clinical data is clear on which enzymes are effective and the levels of activity that are necessary for a therapeutic effect, and unsurprisingly, it is the three that are normally produced by the pancreas:Lipase - breaks down fat (Therapeutic Activity Level: 40,000 FIP)Protease - breaks down proteins (Therapeutic Activity Level: 100,000 HUT)Amylase - breaks down starches (Therapeutic Activity Level: 3,755.5 SKB or 180,264 HUT)Our formulation is the only over the counter product with the clinically relevant enzymes at their recommended levels of activities. Other products contain a fraction of the necessary levels of activity and usually contain many 'filler' enzymes. BoulderBio's enzymes do not contain 'filler' enzymes or blends, ever. Only lipase, protease, amylase, and Nu-flow, a proprietary agent extracted from rice that ensures maximum bioavailability and activity.

All FAQs

If you can’t find what you’re looking for, feel free to contact our support team for assistance.

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Therapeutic Strength Digestive Enzymes