Front view of a 90-capsule bottle of BoulderBio Therapeutic Strength Digestive Enzymes

BoulderBio usage directions: take one capsule with the first bite of each meal or snack and adjust for heavier meals.

Clinical results: 88% reported symptom relief, 73% less bloating and discomfort, and 79% fewer symptoms within 21 days.

Five-star customer review from Kaye P. describing improved comfort after eating with BoulderBio digestive enzymes.

Supplement Facts: protease 100,000 HUT, lipase 40,000 USP, amylase 3,755.5 SKB and 20 mg Nu-Flow.

Two beige BoulderBio digestive enzyme capsules resting in an open hand.

4.8 (141)

Therapeutic Strength Digestive Enzymes

Name: Therapeutic Strength Digestive Enzymes
Brand: BoulderBio
SKU: BB-TS-90
Price: 80.0 USD
Availability: InStock

Patent-pending, clinically-dosed digestive enzymes that deliver full-spectrum pancreatic support without a prescription. Our clean formula is uniquely designed to remain active and potent in both the stomach and small intestine for complete digestive support. The result is enhanced nutrient absorption and calm digestion that restores your comfort after meals. Feel like yourself again without prescriptions or guesswork.

HSA/FSA eligible with

More effective than prescription!

Bryce M.Verified buyer

Finally... I feel normal after eating!

Kaye P.Verified buyer

The best OTC digestive enzymes

Art M.Verified buyer

Supports healthy, efficient digestion
Maximizes nutrient absorption
Promotes sustained energy + daily comfort

Clinician’s Choice

9 out of 10 doctors surveyed recommended BoulderBio Therapeutic Digestive Enzymes for daily use.

Description

Unmatched in potency, purity, and standards, this clinically dosed formula is made from single-source enzymes using small-batch microbial fermentation and enhanced filtration. It’s designed to remain active in both the stomach and small intestine—without the use of coatings or harmful solvents. BoulderBio is the first and only pharmaceutical-grade digestive support available OTC, delivering a level of quality and efficacy you won’t find anywhere else.

How To Use

Ingredients

Close-up of a person holding a digestive enzyme capsule between their teeth.

One Daily Habit for Whole-Gut Support

You may have enzyme deficiency and not even know it. The simplest way to determine if digestive enzymes can solve your ailments is to try them.

Good For

gas

bloating

Low energy

Inflammation

discomfort

bacterial overgrowth

Our enzymes are for optimal digestive support, with exact dosing and rigorous testing you can trust.

88%

experienced symptom relief with as few as 1–2 capsules per meal⁷
73%

average reduction in bloating and abdominal discomfort across all patients^{3, 7}
79%

of all symptoms related to pancreatic insufficiency decreased within the first 21 days^{3, 7}

See The Science

The 3 Proven Enzymes Your Body Needs To Break Down Food

Microscopic visualization representing the digestive enzyme lipase with a purple and blue color scheme.

Lipase 40,000 FIP

At 40,000 FIP, lipase breaks down fats for better absorption, so you feel lighter after meals with less bloating and more energy.

*FIP is equivalent to USP.²

Microscopic visualization representing the digestive enzyme lipase with blue staining

Protease 100,000 HUT

At 100,000 HUT, protease supports protein digestion to help your body repair muscle, strengthen immunity, and recover faster.

Microscopic visualization representing the digestive enzyme amylase with a blue and green color scheme.

Amylase 3,755 SKB

At 3,755 SKB, amylase turns carbohydrates into usable energy, helping prevent energy crashes and keeping you steady throughout the day.

Daily Digestive Support That Adds Up

1 Day

1 Week

4 Weeks

10 Weeks

1 Day

Relief from common digestive symptoms can begin after your first meal, making digestion feel easier and more comfortable.

relieves:

gas

bloating

discomfort

1 Week

Improvement in post-meal fatigue, loose stools, bloating, and urgency may become noticeable, helping digestion feel more stable and predictive.

relieves

fatigue

loose stools

bloating

urgency

4 Weeks

Reductions in digestive irritation, gut reactivity, and inflammation from undigested food may be experienced, supporting a calmer, more comfortable digestive system.

Relieves:

irritation

gut reactivity

inflammation

10 Weeks

Benefits may extend beyond digestion, with improvements in cognitive clarity, nutrient absorption, energy levels, digestive consistency and resilience, microbial balance, and immune signaling.

Relieves:

low energy

brain fog

immune strain

Feature	BoulderBio	Enzymedica Digest Gold	Vital Nutrients Pancreatin Enzymes	Thorne Pancreatic Enzymes
Vegan	check_mark	check_mark	x_mark	x_mark
Available without a prescription	check_mark	check_mark	check_mark	check_mark
Clinically-proven dosage	check_mark	x_mark	x_mark	x_mark
Active in stomach and small intestine	check_mark	check_mark	x_mark	x_mark
Free from fillers and additives	check_mark	x_mark	x_mark	x_mark
Feature	BoulderBio	Leading Prescription Enzyme A	Leading Prescription Enzyme B	Leading Prescription Enzyme C
Vegan	check_mark	x_mark	x_mark	x_mark
Available without a prescription	check_mark	x_mark	x_mark	x_mark
Clinically-proven dosage	check_mark	check_mark	check_mark	check_mark
Active in stomach and small intestine	check_mark	x_mark	x_mark	x_mark
Free from fillers and additives	check_mark	check_mark	x_mark	x_mark

Shadow of hand holding an enzyme capsule against a light blue background

Designed to Exceed Industry Standards

Each enzyme batch is produced in controlled, limited runs to ensure the highest level of care and consistency.

ABOUt US

Exceptional, effective and affordable product!

After refusing to pay for prescription enzymes, I had good success with Vital. Boulder Bio is my new #1 choice. Immediate control, no bloating, easy to take. In my view, the only difference with the prescription is the time release coating. Is this in the future? I have just subscribed to your monthly delivery, and am delighted with the results. Well done. BTW, I live in Boulder if you need any “guinea pigs” for improved products,

Helpful Enzymes!!!

Your digestive enzymes have helped me greatly and been just what the doctor ordered. They were less expensive but more effective than others we had tried.
Your people have been extremely nice and easy to work with and respond quickly to orders and shipment of product.
Thank you for being a great company
Greg Belk

Lifesaver

I was really struggling with pancreatic insufficiency until I got on Boulder Bio’s Digestive Enzymes! What a lifesaver & so much more affordable than the pharmaceuticals big name solutions!

Great product, excellent customer service

This product has been really helpful, and I had a great experience with their customer service when I needed help with my order!

This Changed My Life!

As a person diagnosed and living with Exocrine Pancreatic Insufficiency (EPI) for a while, this product was a game-changer! Since having my gallbladder removed 14 months ago, I have had chronic problems with digestion. My doctor, whom I appreciate because he is always seeking more homeopathic paths to health, informed me that the "standard treatment" is Pancreatic Enzyme Replacement Therapy (PERT). CREON is one in a handful of pharmaceutical medications used in PERT. PERT is porcine (pig) pancreatic enzymes. It is used because the porcine pancreatic enzyme is "similar" to the human. As a lacto-ovo vegetarian for 45 years, it was a challenge to consider consuming pork -- no matter the form. I began intensively researching EPI and it's treatment.

Global research, studies, and clinical trials were available. I learned about fungal enzyme treatments that have been used worldwide. Then I found Boulder Bio. Their website was informative and prompted more investigation. I hand-delivered pages of info I had compiled to my Dr, telling him that I wanted to try the BoulderBio Digestive Enzymes first, before jumping onto the PERT path.

Well, after living on watermelon and canned pears for a long time, I decided to try the Digestive Enzymes from Boulder Bio. WHAT A GAME-CHANGER!

I take 1 capsule before eating my regular foods and no longer experience the intense bloating, abdominal cramping, nausea, or diarrhea. After one week, I was completely sold on this product and have shared my experience with many who have digestive challenges.

Customer service at Boulder Bio is stellar! This is an American company intent on producing the best product....and they do. Try it!

Help At Last

In September 2025 I thought I had gotten bad food at a restaurant as I had diarrhea. After two weeks I was still dealing with having to stay home. I had a close relationship with the bathroom. I finally got an appointment with my primary care and she ordered some stool tests. One came back as mild Exocrine Pancreatic Insufficiency which I had never heard about before. I would not call it mild.m Next came an appointment with a Gastrointerologist. She recommended a prescription for enzymes. My insurance wanted a $254 co-pay which I balked at. Went home and did research on the internet and soon found Boulder Bio. Certainly glad I did. I ordered a bottle to see if it would work. It took a week or two for my system to adjust to the enzymes and I became regulated. I only have to take one pill a day and can now leave the house to go to church, go shopping and travel without worrying whether I will have an accident. I am 84 yrs. Old and extremely glad I found Boulder Bio. Thank you.

Noticeable difference

I notice a big difference when I forget to take Boulderbio with each meal. It takes my body a minute to realize that help is on the way, but as soon as I take it for a full day, I am back to feeling good with energy.

Changed my life

I have Alpha Gal Syndrome and pancreatic problems. These enzymes are mammal free.

Affordable alternative to Creon

After my Whipple procedure, I was prescribed Creon, which worked well, but even with insurance it was way too expensive. Looking for a more affordable option, I found Boulder Bio digestive enzymes and decided to give them a try.

It takes time to find the right dose, and I’m still not quite there yet, but they work well and have been comparable to Creon. While Boulder Bio’s cost is still on the higher end of over-the-counter digestive enzymes, the quality is better than other cheaper brands, and the cost is more manageable than Creon. I’m glad to have found an effective alternative that supports my digestion without the hefty prescription price tag.

Frequently
Asked Questions

All FAQs

What are digestive enzymes and what do they do?

How do I know if digestive enzymes will work for me?

If you suffer from gas, bloating, low energy, pain or sleepiness after eating, inflammation, bacterial overgrowth, or other gastrointestinal discomfort, you may have enzyme deficiency and not even know it. The simplest way to determine if digestive enzymes can solve your ailments is to try them!Enzyme deficiency is far more common than most people think and causes a variety of symptoms. These symptoms are often misattributed by doctors, resulting in an incorrect diagnosis. According to Healthline, pancreatic insufficiency (aka lack of digestive enzymes) is the Number 1 missed diagnosis out of all gastrointestinal conditions. Even when doctors do test for pancreatic function, the test has a high specificity, but a low sensitivity. Basically, this means that it is great at confirming pancreatic insufficiency in the most severe cases, but lower levels of pancreatic insufficiency are not detected. Unfortunately, many of these individuals can go years, decades, or longer living with unresolved GI distress. We will share many of these case studies to our email subscribers as they are what led to BoulderBio's founding.

Why is indigestion a cause for concern?

Undigested food is problematic for two reasons:The nutrients in undigested food are unable to be absorbed by the body, which can cause symptoms such as low energy, brain fog, malnourishment, vitamin deficiency, anxiety, etc.Food is not meant to remain in the digestive tract when undigested, so when it does, it causes symptoms such as inflammation, discomfort (gas, bloating, nausea, etc.), bacterial overgrowth, and more

How is BoulderBio’s formulation superior?

Clinical data is clear on which enzymes are effective and the levels of activity that are necessary for a therapeutic effect, and unsurprisingly, it is the three that are normally produced by the pancreas:Lipase - breaks down fat (Therapeutic Activity Level: 40,000 FIP)Protease - breaks down proteins (Therapeutic Activity Level: 100,000 HUT)Amylase - breaks down starches (Therapeutic Activity Level: 3,755.5 SKB or 180,264 HUT)Our formulation is the only over the counter product with the clinically relevant enzymes at their recommended levels of activities. Other products contain a fraction of the necessary levels of activity and usually contain many 'filler' enzymes. BoulderBio's enzymes do not contain 'filler' enzymes or blends, ever. Only lipase, protease, amylase, and Nu-flow, a proprietary agent extracted from rice that ensures maximum bioavailability and activity.

All FAQs

If you can’t find what you’re looking for, feel free to contact our support team for assistance.

Therapeutic Strength Digestive Enzymes

One Daily Habit for Whole-Gut Support

Science-Backed,
Third-Party Verified

The 3 Proven Enzymes Your Body Needs To Break Down Food

Daily Digestive Support That Adds Up

1 Day

1 Week

4 Weeks

10 Weeks

Better Gut Support
By Design

Designed to Exceed Industry Standards

Customer Reviews

Frequently
Asked Questions

Therapeutic Strength Digestive Enzymes

One Daily Habit for Whole-Gut Support

Science-Backed, Third-Party Verified

The 3 Proven Enzymes Your Body Needs To Break Down Food

Daily Digestive Support That Adds Up

1 Day

1 Week

4 Weeks

10 Weeks

Better Gut Support By Design

Designed to Exceed Industry Standards

Customer Reviews

Frequently Asked Questions

Science-Backed,
Third-Party Verified

Better Gut Support
By Design

Frequently
Asked Questions