Revolutionary Formula
Prescription-Level Potency
40,000 USP Lipase (40,000 FIP), 100,000 HUT Protease, and 3,755.55 SKB Amylase — a potency profile traditionally found only in prescription enzyme products.
Designed for EPI Challenges
Supports the breakdown of fats, proteins, and carbohydrates — the three nutrient categories most affected when the pancreas cannot produce enough digestive enzymes.
Immediate Activity
Unlike enteric-coated enzymes, BoulderBio’s formula becomes active in the stomach and continues working in the small intestine, supporting the entire digestive pathway.
Unmatched Purity
No Chemical Coatings or Additives
Our broad-activity enzymes do not require the plasticizers, excipients, phthalates, or enteric coatings commonly used in prescription products.
Clean, Plant-Based Fermentation
Every batch is produced through small-scale fermentation and purified using a proprietary multi-step filtration process.
Verified Purity
Each lot undergoes extensive third-party testing to confirm potency, identity, and the absence of contaminants.
Premium Quality
Made in the USA
Manufactured in our local, FDA-audited, cGMP-certified facility following strict quality and safety standards.
Regularly Audited
Our facility is routinely inspected by the FDA and independent third-party organizations to ensure compliance and consistency.
Transparent & Traceable
Every bottle is produced, bottled, and tested in the same controlled environment — single-source enzymes, local manufacturing
Rated 4.8/5 from 133 Reviews
High Potency Digestive Enzymes
Patent-Pending. No Prescription Required.
At 10x the potency of average mass market enzyme products, each capsule contains 40,000 FIP (40,000 USP) lipase. This is the AGA recommended starting dose for pancreatic enzyme therapy.
Our patent-pending vegan enzyme formula is built for activity across the full digestive process. BoulderBio starts working in the stomach and continues into the small intestine for complete, full-spectrum digestive relief.
BoulderBio's purity sets it apart from every other enzyme product on the market - no animal byproducts, no enteric coating chemicals, no plasticizers, phthalates, dyes, or unnecessary fillers.
High-dose lipase for fat digestion
Protease + amylase support for proteins & carbs
Acid-resistant microbial enzymes start working in the stomach
Maintains digestive activity in the small intestine
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/every month
Revolutionary Formula
Prescription-Level Potency
40,000 USP Lipase (40,000 FIP), 100,000 HUT Protease, and 3,755.55 SKB Amylase — a potency profile traditionally found only in prescription enzyme products.
Designed for EPI Challenges
Supports the breakdown of fats, proteins, and carbohydrates — the three nutrient categories most affected when the pancreas cannot produce enough digestive enzymes.
Immediate Activity
Unlike enteric-coated enzymes, BoulderBio’s formula becomes active in the stomach and continues working in the small intestine, supporting the entire digestive pathway.
Unmatched Purity
No Chemical Coatings or Additives
Our broad-activity enzymes do not require the plasticizers, excipients, phthalates, or enteric coatings commonly used in prescription products.
Clean, Plant-Based Fermentation
Every batch is produced through small-scale fermentation and purified using a proprietary multi-step filtration process.
Verified Purity
Each lot undergoes extensive third-party testing to confirm potency, identity, and the absence of contaminants.
Premium Quality
Made in the USA
Manufactured in our local, FDA-audited, cGMP-certified facility following strict quality and safety standards.
Regularly Audited
Our facility is routinely inspected by the FDA and independent third-party organizations to ensure compliance and consistency.
Transparent & Traceable
Every bottle is produced, bottled, and tested in the same controlled environment — single-source enzymes, local manufacturing
No Coating
No Phthalates
Clinically Dosed
40,000 FIP Lipase
cGMP-Certified
Local US Manufacturing
Patent-Pending
Full-Spectrum Support
A Modern Approach to Enzyme Therapy
For years, digestive enzyme therapy came with a tradeoff. Traditional prescription pancreatic enzymes are high activity, but they are animal-based, enteric-coated, and available only by prescription. Mass-market enzyme supplements are easier to buy, but many are low potency, poorly standardized, or built for broad digestive wellness rather than serious enzyme support.
BoulderBio was developed to provide quality OTC pancreatic support
A high-potency, over-the-counter enzyme formula designed around enzyme activity, acid resistance, and real digestive function. Decades of research lead to our patent-pending formula that starts working in the stomach and continues through the small intestine.
One of a kind, available without a prescription.
Prescription Strength Digestive Enzymes
Many people searching for prescription-strength digestive enzymes are looking for the highest level of enzyme activity. The most important measure of enzyme strength is lipase potency.
Lipase is responsible for breaking down dietary fats and is the digestive enzyme most impacted by reduced pancreatic function. For that reason, its activity is the primary benchmark used to compare the strength of pancreatic enzyme therapies.
That is why BoulderBio starts with 40,000 USP/FIP lipase per serving — a therapeutic-strength amount designed for people who need more than a typical digestive enzyme blend. Paired with high-activity protease and amylase to support protein and carbohydrate digestion.
Different By Design
Built to work from the stomach to the small intestine.
Many enzyme products depend on enteric coating to protect enzymes from stomach acid. BoulderBio takes a different approach.
Our microbial enzymes are designed for acid resistance, so they can begin working in the stomach and continue supporting digestion as food moves into the small intestine.
Different By Design
Built to work from the stomach to the small intestine.
Many enzyme products depend on enteric coating to protect enzymes from stomach acid. BoulderBio takes a different approach.
Our microbial enzymes are designed for acid resistance, so they can begin working in the stomach and continue supporting digestion as food moves into the small intestine.
Clinically Grounded, Patient Trusted.
What Better Digestion Can Feel Like
Reduced Post-Meal Bloating
Cleaner, Smoother Bowel Movements
Enhanced Nutrient Absorption
Alleviated Gas & Stomach Cramps
Freedom From Mealtime Stress
Daily Digestive Support That Adds Up
1 Day
Relief from common digestive symptoms can begin after your first meal, making digestion feel easier and more comfortable.
1 Week
Improvement in post-meal fatigue, loose stools, bloating, and urgency may become noticeable, helping digestion feel more stable and predictive.
4 Weeks
Reductions in digestive irritation, gut reactivity, and inflammation from undigested food may be experienced, supporting a calmer, more comfortable digestive system.
10 Weeks
Benefits may extend beyond digestion, with improvements in cognitive clarity, nutrient absorption, energy levels, digestive consistency and resilience, microbial balance, and immune signaling.
Frequently Asked Questions
What makes BoulderBio different from prescription enzymes?
Prescription enzymes are typically enteric-coated and activate later in digestion. BoulderBio’s plant-based enzymes become active immediately in the stomach and continue working through the small intestine.
BoulderBio was created for those who wanted a clean, vegan, and effective alternative to animal-based prescription enzymes.
Is 40,000 USP lipase a strong potency?
Yes. 40,000 USP lipase is a clinically meaningful potency level commonly found in prescription-strength enzyme products. The AGA recommended therapeutic dose for digestive enzymes is between 40,000-200,000 USP lipase. BoulderBio offers this lipase activity in a clean, plant-based format.
To put this number in perspective, a healthy pancreas produces an average of about 500,000 USP lipase per meal.
How soon will I notice digestive support?
Many customers report noticing changes within the first few meals, especially with higher-fat or higher-protein foods. Individual experiences vary based on meal size and overall digestive needs. Some symptoms may take longer to resolve.
How many bottles do most users need per month?
For most customers, 1–2 bottles per month is sufficient. Each bottle contains 90 capsules. If you're taking one capsule with each meal, one bottle will typically last about a month. If you find you need two capsules per meal, you'll likely use two bottles per month and so on. Your ideal serving size depends on your individual needs and the size and fat content of your meals. Always consult your doctor before starting any regimen.
Is BoulderBio safe for everyday use?
BoulderBio is manufactured in a cGMP-certified, FDA-audited facility and is third-party tested for purity, potency, and identity. Many people use digestive enzymes daily as part of their ongoing routine.
What if I can't swallow capsules?
The capsules can be opened and the contents sprinkled onto soft, cool food such as applesauce or yogurt. Avoid hot foods, as high heat may reduce enzyme activity.
How is BoulderBio effective without an enteric coating?
Traditional enzyme therapy was built around a limitation: animal-based enzymes can't survive stomach acid. That's why prescription enzymes require an enteric coating—to shield the enzymes until they reach the small intestine.
BoulderBio's patent-pending enzyme technology is acid-stable, allowing the enzymes to begin working in the stomach and continue activity throughout the small intestine. Instead of protecting enzymes from stomach acid, our enzymes are designed to function in it.
The result is digestive activity that starts sooner, continues longer, and doesn't require a chemical enteric coating. Same goal. Completely different technology.