Revolutionary Formula
Prescription-Level Potency
40,000 USP Lipase (40,000 FIP), 100,000 HUT Protease, and 3,755.55 SKB Amylase — a potency profile traditionally found only in prescription enzyme products.
Designed for EPI Challenges
Supports the breakdown of fats, proteins, and carbohydrates — the three nutrient categories most affected when the pancreas cannot produce enough digestive enzymes.
Immediate Activity
Unlike enteric-coated enzymes, BoulderBio’s formula becomes active in the stomach and continues working in the small intestine, supporting the entire digestive pathway.
Unmatched Purity
No Chemical Coatings or Additives
Our broad-activity enzymes do not require the plasticizers, excipients, phthalates, or enteric coatings commonly used in prescription products.
Clean, Plant-Based Fermentation
Every batch is produced through small-scale fermentation and purified using a proprietary multi-step filtration process.
Verified Purity
Each lot undergoes extensive third-party testing to confirm potency, identity, and the absence of contaminants.
Premium Quality
Made in the USA
Manufactured in our local, FDA-audited, cGMP-certified facility following strict quality and safety standards.
Regularly Audited
Our facility is routinely inspected by the FDA and independent third-party organizations to ensure compliance and consistency.
Transparent & Traceable
Every bottle is produced, bottled, and tested in the same controlled environment — single-source enzymes, local manufacturing
Rated 4.8/5 from 133 Reviews
Clinically Dosed Digestive Enzymes for EPI
BoulderBio is an over the counter solution to support patients with exocrine pancreatic insufficiency. Our patent-pending formula delivers 40,000 USP (40,000 FIP) lipase— clinical strength pancreatic enzyme replacement therapy but with clean, plant-based enzymes instead of animal pancreas.
High-dose lipase for fat digestion
Protease + amylase support for proteins & carbs
No coatings, fillers, or plasticizers
Works immediately in the stomach and continues through the small intestine without an enteric coating
If you’re searching for over-the-counter enzyme replacement for EPI, a vegan pancreatic enzyme, or real support for pancreatic insufficiency, this formula was built for that moment.
Clear ingredients. Clinical strength. Real digestive support
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Revolutionary Formula
Prescription-Level Potency
40,000 USP Lipase (40,000 FIP), 100,000 HUT Protease, and 3,755.55 SKB Amylase — a potency profile traditionally found only in prescription enzyme products.
Designed for EPI Challenges
Supports the breakdown of fats, proteins, and carbohydrates — the three nutrient categories most affected when the pancreas cannot produce enough digestive enzymes.
Immediate Activity
Unlike enteric-coated enzymes, BoulderBio’s formula becomes active in the stomach and continues working in the small intestine, supporting the entire digestive pathway.
Unmatched Purity
No Chemical Coatings or Additives
Our broad-activity enzymes do not require the plasticizers, excipients, phthalates, or enteric coatings commonly used in prescription products.
Clean, Plant-Based Fermentation
Every batch is produced through small-scale fermentation and purified using a proprietary multi-step filtration process.
Verified Purity
Each lot undergoes extensive third-party testing to confirm potency, identity, and the absence of contaminants.
Premium Quality
Made in the USA
Manufactured in our local, FDA-audited, cGMP-certified facility following strict quality and safety standards.
Regularly Audited
Our facility is routinely inspected by the FDA and independent third-party organizations to ensure compliance and consistency.
Transparent & Traceable
Every bottle is produced, bottled, and tested in the same controlled environment — single-source enzymes, local manufacturing
Clean Ingredients,
Tested for Purity
Clinically Dosed,
Rx Strength
FDA Audited,
USA, cGMP Facility
Patent-pending formula works without an enteric coating
Take The Stress Out of Mealtime
If you have EPI, you've probably spent enough time worrying about food. Wondering whether a meal will cause symptoms. Planning your day around bathrooms. Skipping foods you love because they don't seem worth the risk.
We believe eating should be enjoyable again.
BoulderBio was developed to provide therapeutic-strength digestive enzyme support with a patent-pending formula that starts working in the stomach and continues through the small intestine.
Because life is hard enough without worrying about every meal.
The BoulderBio Solution
Pancreatic insufficiency is one of the most common digestive disorders, yet it is also one of the most overlooked. Many people spend years suffering before diagnosis, or result to self diagnosis.
Prescription enzymes often come at a high cost. It can be thousands out of pocket to try prescription enzymes without insurance. The lesser known cost is the ingredients that hide in these enzymes - plasticizers, pthalates, dyes, animal organs etc.
BoulderBio was created to bridge this gap. Completely natural, clean, and plant-based, our enzymes provide EPI patients with the world's first over-the-counter support.
Clinically Grounded, Patient Trusted.
Reclaim Your Gut Health
Combat Post-Meal Bloating
Enjoy Cleaner, Smoother Bowel Movements
Enhance Nutrient Absorption
Alleviate Gas & Stomach Cramps
Reduce Mealtime Stress
Daily Digestive Support That Adds Up
1 Day
Relief from common digestive symptoms can begin after your first meal, making digestion feel easier and more comfortable.
1 Week
Improvement in post-meal fatigue, loose stools, bloating, and urgency may become noticeable, helping digestion feel more stable and predictive.
4 Weeks
Reductions in digestive irritation, gut reactivity, and inflammation from undigested food may be experienced, supporting a calmer, more comfortable digestive system.
10 Weeks
Benefits may extend beyond digestion, with improvements in cognitive clarity, nutrient absorption, energy levels, digestive consistency and resilience, microbial balance, and immune signaling.
Frequently Asked Questions
What makes BoulderBio different from prescription enzymes?
Prescription enzymes are typically enteric-coated and activate later in digestion. BoulderBio’s plant-based enzymes become active immediately in the stomach and continue working through the small intestine.
BoulderBio was created for those who wanted a clean, vegan, and effective alternative to animal-based prescription enzymes.
Is 40,000 USP lipase a strong potency?
Yes. 40,000 USP lipase is a clinically meaningful potency level commonly found in prescription-strength enzyme products. The AGA recommended therapeutic dose for digestive enzymes is between 40,000-200,000 USP lipase. BoulderBio offers this lipase activity in a clean, plant-based format.
To put this number in perspective, a healthy pancreas produces an average of about 500,000 USP lipase per meal.
How soon will I notice digestive support?
Many customers report noticing changes within the first few meals, especially with higher-fat or higher-protein foods. Individual experiences vary based on meal size and overall digestive needs. Some symptoms may take longer to resolve.
How many bottles do most users need per month?
For most customers, 1–2 bottles per month is sufficient. Each bottle contains 90 capsules. If you're taking one capsule with each meal, one bottle will typically last about a month. If you find you need two capsules per meal, you'll likely use two bottles per month and so on. Your ideal serving size depends on your individual needs and the size and fat content of your meals. Always consult your doctor before starting any regimen.
Is BoulderBio safe for everyday use?
BoulderBio is manufactured in a cGMP-certified, FDA-audited facility and is third-party tested for purity, potency, and identity. Many people use digestive enzymes daily as part of their ongoing routine.
What if I can't swallow capsules?
The capsules can be opened and the contents sprinkled onto soft, cool food such as applesauce or yogurt. Avoid hot foods, as high heat may reduce enzyme activity.
How is BoulderBio effective without an enteric coating?
Traditional enzyme therapy was built around a limitation: animal-based enzymes can't survive stomach acid. That's why prescription enzymes require an enteric coating—to shield the enzymes until they reach the small intestine.
BoulderBio's patent-pending enzyme technology is acid-stable, allowing the enzymes to begin working in the stomach and continue activity throughout the small intestine. Instead of protecting enzymes from stomach acid, our enzymes are designed to function in it.
The result is digestive activity that starts sooner, continues longer, and doesn't require a chemical enteric coating. Same goal. Completely different technology.